منابع مشابه
PubChem3D: Conformer generation
BACKGROUND PubChem, an open archive for the biological activities of small molecules, provides search and analysis tools to assist users in locating desired information. Many of these tools focus on the notion of chemical structure similarity at some level. PubChem3D enables similarity of chemical structure 3-D conformers to augment the existing similarity of 2-D chemical structure graphs. It i...
متن کاملPubChem3D: conformer ensemble accuracy
UNLABELLED BACKGROUND PubChem is a free and publicly available resource containing substance descriptions and their associated biological activity information. PubChem3D is an extension to PubChem containing computationally-derived three-dimensional (3-D) structures of small molecules. All the tools and services that are a part of PubChem3D rely upon the quality of the 3-D conformer models. ...
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Social recommendations have been found to increase the product adoption probability. However, very few studies have considered the impact of social opinions on the users’ evaluation of the product. In social networks, many times users’ opinions are not completely independent from their friends and users tend to change their rating such that they are more similar to the social opinions. Understa...
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The ClpXP protease of bacteria can degrade a wide variety of proteins while maintaining remarkable substrate selectivity. New work in Escherichia coli implicates adaptor proteins in enhancing substrate selectivity and regulating the flow of substrates to cellular proteases.
متن کاملMonopolar spindle 1 (MPS1) kinase promotes production of closed MAD2 (C-MAD2) conformer and assembly of the mitotic checkpoint complex.
MPS1 kinase is an essential component of the spindle assembly checkpoint (SAC), but its functioning mechanisms are not fully understood. We have shown recently that direct interaction between BUBR1 and MAD2 is critical for assembly and function of the human mitotic checkpoint complex (MCC), the SAC effector. Here we report that inhibition of MPS1 kinase activity by reversine disrupts BUBR1-MAD2...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2006
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2006.07.001